A very compelling book that can be hard to put down, I read the whole book in a day! Jack gives his own story of going from dentist to neurosurgeon to health detective, and putting the puzzle together of the many failings of the medical system. While Kruse can be obnoxious at times, there is amazing information about leptin resistance, an extremely widespread yet not commonly know issue. The chapters about obesity, diabetes and the chapter "Proof the Epi-Paleo Rx is the paleolithic diet of all time" are especially mind-blowing.